The Nikkei average dipped 1.63 percent to 51,117.26 while the broader Topix index closed 0.77 percent lower at 3,484.34.
Shin-Etsu Chemical shares slumped 4 percent as China launched an anti-dumping probe into Japanese chipmaking chemicals.
Technology stocks also lost ground, with semiconductor-linked names such as SoftBank, Advantest and Tokyo Electron falling 2-8 percent.
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